Journal article
Enhanced brain responsiveness during active emotional face processing in obsessive compulsive disorder
N Cardoner, BJ Harrison, J Pujol, C Soriano-Mas, R Herńndez-Ribas, M López-Solá, E Real, J Deus, H Ortiz, P Alonso, JM Menchãn
World Journal of Biological Psychiatry | Published : 2011
Abstract
Objectives. The abnormal processing of emotional stimuli is common to a variety of psychiatric disorders. Specifically, patients with prominent anxiety symptoms generally overreact to emotional cues, which has been linked to increased amygdala activation. However, in OCD, enhanced responses are predominantly obtained using disease-specific stimuli and preferentially involve frontostriatal systems. Methods. We assessed 21 OCD patients and 21 healthy controls with fMRI during an emotional face-processing paradigm involving active response generation to test for alterations in both brain activation and task-induced functional connectivity of the frontal cortex, the amygdala and the fusiform fac..
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Grants
Awarded by Florida Polytechnic University
Funding Acknowledgements
This study was supported in part by the Instituto de Salud Carlos III, Centro de Investigacion en Red de Salud Mental, CIBERSAM (FIS, I.D. PI050884 & PI071029). Dr Harrison is supported by a National Health and Medical Research Council of Australia (NHMRC) Clinical Career Development Award (I.D. 628509). Dr Pujol acknowledges contribution from the Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Barcelona, Spain. Dr. Soriano-Mas is funded by a Miguel Servet contract from the Carlos III Health Institute (CP10/00604). Ms Lopez-Sola is supported by FPU grants from the Spanish Ministry of Education (I.D. AP2005-0408). Ms Real was funded by the Institut d'Investigacio Biomedica de Bellvitge (IDIBELL). We thank Gerald Fannon for revising the manuscript. The authors thank all the study participants and staff from the Department of Psychiatry of Hospital Universitari de Bellvitge who helped enroll the study sample. Dr Cardoner had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.